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A team led by Professor X. David Li, Department of Chemistry, University of Hong Kong, has developed a new chemical tool to elucidate the network of intracellular protein interactions. This tool not only facilitates the identification of interacting partners of proteins in a complex cellular environment, but also simultaneously allows the “visualization” of the interactions of these proteins. These findings were recently published in Molecular Cells.

In the human body, proteins interact and cooperate to regulate every biological process from gene expression and signal transduction to immune response. Thus, dysregulation of protein interactions often leads to human diseases, such as cancer and Alzheimer’s disease. In modern biology, a comprehensive understanding of protein interaction networks is important, which has implications for disease diagnosis and can facilitate the development of therapies.

To dissect complex protein networks, two questions need to be answered: the protein binds to “who” and “how.” Who “refers to the recognition of protein interaction partners, while “how” refers to specific “binding regions” that mediate these interactions. Answering these questions is challenging because protein interactions are often too unstable and too transient to detect. To solve this problem, Professor Li’s team previously developed a series of tools to “capture” interactions between proteins through chemical bonds. Possibly, because these tools are equipped with a special light-activated “camera”, the diazinyl group, which can capture each binding partner of the protein when exposed to ultraviolet light. These interactions can then be examined and interpreted. Unfortunately, the “resolution” of this “camera” is relatively low, which means that key information about how proteins interact is lost. To this end, Professor Li’s team has now designed a new tool (called ADdis-Cys) that has an upgraded “camera” to improve “resolution”. An alkyne stalk was mounted next to the diazoxide, and the binding region of the protein could be clearly seen “zoomed in”. Combined with state-of-the-art mass spectrometry techniques, ADdis-Cys is the first tool capable of simultaneously identifying protein interaction partners and pinpointing their binding regions.

In the published paper, Professor Li’s laboratory was able to comprehensively identify many protein interactions, some known and some newly discovered, that are important for regulating important cellular processes, such as DNA replication, gene transcription, and DNA damage repair. Most importantly, Professor Li’s laboratory was able to use ADdis-Cys to reveal the binding regions that mediate the interactions of these proteins. Tools may lead to the development of chemical modulators that modulate protein interactions to treat human diseases. As a research tool, adis-cys will discover far-reaching applications in many research fields, particularly in the diagnosis and treatment of diseases.

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If you are wondering why the American Dental Association recommends people to visit their dentists once every six months, then note carefully – that because it’s critical for the protection of dental and oral health. Oral health is fundamental for you since it’s proven to affect the in-general wellbeing while owning shining white teeth helps boost your self-esteem.

On the contrary, an unsightly smile due to your discolored chipped teeth or bad breath not only destructs your personality but makes you unwelcoming in society. So, it’s high time to take the matter seriously and search for ‘doctors accepting new patients near me’ through needed research. Here’s a list of tips for you to find a professional dentist and reach your goal.

Research with Diligence

Getting referrals from family relations, friends, and associates who are living in the same locality or neighbors as well as listening to the market buzz is a productive way to find your dentist in the fastest way. However, as it always doesn’t work, an ideal way to find your desired densest is the web world. Keeping in mind that hurry leads to wrong decision making, take adequate time to research the internet and take Google’s assistance while searching ‘ doctors accepting new patients near me’ will get you a list of the most popular dentists in your neighboring. Stick to the first page on SERPs and browse websites of the background of each practitioner, his/her medical background, specialization area, and other factors as stated.

Background

The background of your dentist is undeniably a major determining factor since the background of a physician contributes a lot to their professionalism, behavior, and attitudes. That is why knowing the background should be given priority in your decision-making. Verify the educational and professional background. Also, ensure that he/she is a certified fellow of the American Board of Dentistry and also operational with the required State Dental Association that allows them to render services to patients. The professional should hold certification in general dentistry and surgery.

Specialization Area

When on the lookout for ‘doctors accepting near patients near me’, never make a mistake to make certain that the dentist is prepared to attend dental emergency cases. Since, dental emergencies like acute dental ache caused by infection, oral injury, or impacted wisdom teeth are quite common in every household, and that needs emergency intervention, it should be one of your determinants.

Secondly, whatever maybe you dental problem at this moment, when choosing your dentist make sure that the professional is specializing in across-the-board oral care service bearing in mind that you or your family loved may come across some other kind of issue tomorrow when you don’t have to seek some other dentist’s assistance. So, always choose a dentist who is competent enough to provide the complete range of solutions including preventive dentistry, cosmetic dentistry, dental surgery, or endodontics, and having expertise in sedation dentistry.

Cleanliness and Organization

Reputable Dental clinics should follow FDA-grade disinfectants standards throughout the setting and in their practices to keep patients safe. Verify if the doctor and his/her assistants use property sterilized instruments, wear gloves, use masks to stop spreading infections. The doctor, clinicians, and receptionist should be well organized, accommodating, and caring to the patients.

Dental Equipments and Tools

In order to provide the updated standard of dental and oral care services, ‘doctors accepting new patients near me’ must be operational with the advent-grade 3D X-ray machine, CAD/CAM system, CT scanner, 3D imaging software integrated digital camera as well as CEREC device that helps designing of customized dental crowns or veneers faster and in-house.

Conclusion:

If the above points are up to the mark and you feel confident to get started, the last thing you should verify whether or not the dentist is tied up with PPO dental insurance service providers. With insurance backup, all kinds of dental services become affordable to patients.